A non-ClickOnce deployment does not give you the advantages of managing updates to privileges, permissions, or software upgrades. A non-ClickOnce deployment is done typically for testing or development purposes where the agent workstation is not in a production environment. Only the Interaction Workspace application is installed on the client workstation.
Non-ClickOnce Deployment Prerequisites
Interaction Workspace runs on the following client-side operating systems: Windows XP, Vista, 2003, or 2008. The workstation must have the .NET Framework 3.5, SP 1 installed. The following browsers are supported: Microsoft Internet Explorer 6, 7, and 8; and Mozilla Firefox 2 and 3.
Mass Deployment of .NET Framework
If you do not have the .NET Framework installed on all of your client workstation, you can use the procedures found on the Microsoft Developer Network to perform a mass deployment. http://msdn.microsoft.com/en-us/library/cc160717.aspx